Sample MCQ 1A patient with beta-thalassemia major receiving repeated transfusions is at risk for which long-term complication?A. Iron overloadB. Vitamin C deficiency onlyC. Severe thrombocytosis alwaysD. Hypercoagulability never occursShow Answer & ExplanationCorrect Answer: Option AChronic transfusions cause iron accumulation that can damage the heart, liver and endocrine organs unless appropriately monitored and chelated.
Sample MCQ 2A pregnant woman with prior unprovoked DVT requires anticoagulation. Which agent is generally preferred during pregnancy?A. Low-molecular-weight heparinB. Warfarin throughout pregnancyC. A direct oral anticoagulant as first choiceD. Aspirin aloneShow Answer & ExplanationCorrect Answer: Option ALMWH is commonly preferred for treatment and prevention of venous thromboembolism during pregnancy because it does not cross the placenta.
Sample MCQ 3A patient with polycythemia vera is most likely to have which mutation?A. JAK2 mutationB. BCR-ABL1C. Factor V Leiden onlyD. HFE C282Y onlyShow Answer & ExplanationCorrect Answer: Option AMost patients with polycythemia vera have a JAK2 driver mutation causing constitutive signaling.
Sample MCQ 4Which finding suggests hemolysis?A. High LDH, low haptoglobin and indirect hyperbilirubinemiaB. Low LDH and high haptoglobinC. Direct hyperbilirubinemia only with normal reticulocytesD. Low reticulocyte count in all casesShow Answer & ExplanationCorrect Answer: Option ARed-cell destruction releases LDH and hemoglobin, lowers haptoglobin and increases unconjugated bilirubin; reticulocytes usually rise if marrow function is intact.
Sample MCQ 5A patient has bone pain, anemia, renal impairment, hypercalcemia and a monoclonal protein. What is the most likely diagnosis?A. Multiple myelomaB. Polycythemia veraC. ITPD. Thalassemia traitShow Answer & ExplanationCorrect Answer: Option AThe CRAB features—hyperCalcemia, Renal dysfunction, Anemia and Bone disease—are classic for symptomatic multiple myeloma.